Heparanase attenuates axon degeneration following sciatic nerve transection
نویسندگان
چکیده
منابع مشابه
P187: Dose-Dependent Delay of Wallerian Degeneration Induced by Dexamethasone after Sciatic Nerve Transection in Rat
Wallerian degeneration is an innate immune response which occurs after some kinds of nerve damages such as neurodegenerative disease and acute axonal injury. In clinic, dexamethasone as an anti-inflammatory drug has been used for many years to treat nerve injuries. In present study, we aimed to study the effects of various doses of dexamethasone on the Wallerian degeneration in rat. Twentyseven ...
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Functional recovery following experimental nerve injury has been notoriously difficult to quantify precisely. The current gold standard in the rat sciatic nerve model involves analysis of footprints of the recovering animal, and computation of the sciatic function index (SFI). We performed transection injuries and measured recovery both by walking track analysis and by a newer, simpler, more qu...
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Peripheral nerve injury induces inflammation and oxidative stress, which are the most significant causes of the neuronal death. Alpha Lipoic acid (ɑ-LA) as a potent antioxidant and anti-inflammatory agent may counteract the oxidative stress and inflammatory response. This study was designed to investigate the protective effect of ɑ-LA on neuronal cell death in L4 dorsal root ganglion (L4-DRG) i...
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متن کاملPhosphorylation of neurofilament proteins and chromatolysis following transection of rat sciatic nerve.
States of phosphorylation of neurofilament proteins were examined in the perikarya of rat sensory and motor neurons between 3 and 28 d following either a distal transection [6-7 cm from the L4-L5 dorsal root ganglia (DRG)] or a proximal transection (1-2 cm from the L4-L5 DRG) of the sciatic nerve. Paraffin sections of the right (experimental) and left (control) L4 and L5 DRG from animals with u...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2018
ISSN: 2045-2322
DOI: 10.1038/s41598-018-23070-6